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As homozygous knockout of the Men1 gene led to embryonic lethality, it was desirable to develop conditional targeting of the Men1 gene to investigate the function of menin in vario@The geno-mic localization of the Menin-MLL complex at TSSs of the HOX gene locus implicated Menin in organismal development, helping to explain its embryonic lethality and role in "May 1, 2003 · Generation of mice with a null-mutation in the Men1 gene revealed a crucial role for its product, menin, in embryonic development. We show that embryos lacking menin|Sep 21, 2024 · Menin is expressed in all tissues 4, 5 and is essential for proper development, as the homozygous deletion of Men1 in mice is embryonic lethal at E11.5–13.5 as .Feb 22, 2022 · Menin, encoded by the Men1, is a multifunctional scaffold protein participating in a variety of cellular functions, whose deficiency contributes to embryonic lethal"These tumors show somatic inactivation of the normal MEN1 allele by mutation or deletion, resulting in the complete loss of menin function._Jun 1, 2003 · In mice, homozygous deletion of MEN1 is lethal in utero due to multiple developmental delay and craniofacial, cardiac, neural, and hepatic abnormalities 19,33, 52.